A cell surface‐reducing microenvironment induces early osteogenic commitment

Stem cell-based therapy has been highlighted as a potential avenue to promote tissue regeneration, where stimulation of stem cells differentiate into the targeted cell type is essential. One factors that induce their surrounding microenvironment. In this study, correlation between mild reductant and early osteogenic commitment was evaluated. A surface-reducing microenvironment significantly silenced transforming growth factor (TGF)-β signaling pathway mesenchymal (MSCs), followed by increased focal adhesion inhibition membrane protein dimerization. Furthermore, in vivo transplantation MSCs exposed reducing resulted an neobone formation. Thus, these results highlight influence commitment.